Laboratory of Biophysical Chemistry of Protein Complexes is looking for PhD studentTitle of the PhD project: Molecular basis of apoptosis signal-regulating kinase 1 (ASK1) regulation
PhD project: Regulatory mechanisms of C2-WW-HECT (Nedd4-like) E3 ubiquitin ligases and the role of protein-protein interactions in their regulation
We are a young, international research team that studies metabolism in the context of healthy and tumor tissue, using genetic mouse models, metabolic approaches and omics technologies. Previously we discovered that quiescent endothelial cells re-wire metabolism to maintain stress resistance and found a major role for oxidative phosphorylation and autophagy in this process (Magalhaes-Novais et al, Autophagy, 2022). Now we plan to build on these findings and map the metabolism of quiescent endothelium in more detail, to identify molecular mechanisms of metabolic stress resistance with relevance to disease.
The well-established Laboratory Consortium for Research in Haematooncology and Stem Cells, under the leadership of Prof. Tomáš Stopka, announces a call for 2 candidates for PhD studies. The laboratories are located in BIOCEV - a scientific centre of excellence in biotechnology and biomedicine equipped with state-of-the-art instruments and facilities, which brings together top teams of erudite scientists from institutes of the Czech Academy of Sciences and two faculties of Charles University.
CLIP Laboratories are integral part of the Department of Pediatric Hematology and Oncology at the Second Faculty of Medicine, Charles University in Prague. It is the largest pediatric oncology center in the Czech Republic with about 250 newly diagnosed patients per year. CLIP Laboratories are responsible for diagnostics and monitoring of disease progression and treatment efficacy of hematological malignancies. Besides diagnostics, CLIP conducts also internationally recognised research in the field of haematological diseases.
Faculty of Science, Charles University, has an open position for research-technical staff scientist in electron microscopy for Imaging Methods Core Facility at BIOCEV center
Laboratory of Protein engineering is looking for talented PhD students to join our team and helping us to address the appealing question: What variant of SARS-CoV-2 will emerge next? This project sprouts on our previous successful applications of protein engineering in SARS-CoV-2 research (1, 2) and extends it for further exploration of protein interaction plasticity. The research will combine aspect of protein engineering, immunology, virology and bioinformatics.
We are looking for a highly motivated postdoctoral fellow to work with us on addressing questions related to SARS-CoV-2 evolution and to use in vitro evolution techniques for exploring viral sequence space and mutational pathways. Our ultimate goal is to predict the future mutations by combinations of affinity-restricted mutagenesis and antibody escape selections.